Modafinil, while beneficial for treating excessive sleepiness, has specific contraindications that individuals should be aware of before initiating treatment. Below is a summary of who should not take modafinil based on information from multiple medical sources:

Contraindications

1. Allergic Reactions: Individuals with known hypersensitivity to modafinil or its active ingredient should avoid using this medication. This includes anyone who has experienced an allergic reaction or developed a skin rash while taking modafinil, Provigil, or armodafinil.

2. Cardiovascular Conditions: Modafinil is not recommended for patients with a history of heart disease, such as left ventricular hypertrophy or mitral valve prolapse, particularly in those who have received central nervous system (CNS) stimulants previously. This is due to potential increased risk associated with stimulant medications in these populations.

3. Psychiatric Disorders: Those with psychiatric conditions or a history of psychosis may not be suitable candidates for modafinil, as it may exacerbate symptoms or lead to associated risks.

4. Pregnancy and Breastfeeding: While not explicitly mentioned in all sources, caution is typically advised for pregnant or breastfeeding women. It's essential to discuss potential risks with a healthcare provider.

5. Interactions with Other Medications: There can be significant interactions with other drugs, particularly those that affect liver enzymes such as CYP2C19 inhibitors. Individuals taking these medications should consult with their healthcare provider before taking modafinil.

6. Other Health Conditions: Modafinil may have interactions or contraindications in individuals with hypertension or other significant medical conditions.

For comprehensive guidance, it is always advisable to consult medical professionals and refer to trusted medical resources. For more detailed information, you can check these sources:

• Cleveland Clinic
• Mayo Clinic
• WebMD
• Drugs.com

Remember, a discussion with a healthcare provider is crucial for personal medical advice concerning the use of modafinil.

Sources

Modafinil (Provigil): Uses, Interactions & Side Effects - Cleveland ClinicModafinil (oral route) - Mayo ClinicModafinil (Provigil): Uses, Side Effects, Interactions ... - WebMDModafinil Interactions Checker - Drugs.comProvigil (Modafinil): Side Effects, Uses, Dosage, Interactions, WarningsModafinil Information from Drugs.comProvigil (modafinil) dosing, indications, interactions ... - Medscape

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