The texts highlight the prevalence and impact of comorbidities in patients with chronic obstructive pulmonary disease (COPD). Comorbidities refer to other chronic medical conditions, such as coronary artery disease, diabetes mellitus, osteoporosis, and muscle weakness, that are commonly present in patients with COPD. The presence of comorbidities is associated with systemic inflammation and can worsen conditions like ischemic heart disease, heart failure, and lung disease. Notably, COPD is associated with a higher prevalence of comorbidities compared to other diseases, and certain comorbidities, like hypertension and dyslipidemia, are more frequent in patients with severe COPD. Furthermore, comorbidities like pulmonary artery disease, malnutrition, and systemic venous thromboembolism can directly result from COPD. In order to effectively manage COPD, comorbidities should also be taken into consideration.