When it comes to treating headaches, the choice between Tylenol (acetaminophen), Bayer (aspirin), and Excedrin can depend on the type of headache and individual preferences.

Effectiveness:

• Excedrin is often considered one of the most effective over-the-counter options specifically for migraine and tension-type headaches, as it combines acetaminophen, aspirin, and caffeine. Studies show it can outperform Tylenol for headache relief. You can read more about this comparison here.
• Tylenol (Acetaminophen) is effective for mild to moderate headaches and is gentle on the stomach, making it a good option for those who might be sensitive to NSAIDs (non-steroidal anti-inflammatory drugs).
• Bayer (Aspirin) is also effective for headaches but can cause stomach irritation in some individuals. It is a good choice for treating tension headaches and is also anti-inflammatory.

In general, the effectiveness of these medications can vary based on the headache type, and many people find that Excedrin works best for them.

Taking them with Aleve (Naproxen): As for taking these medications within four hours of having taken Aleve, it's generally advisable to avoid mixing NSAIDs if possible. Aleve is an NSAID, and taking it in conjunction with other NSAIDs like aspirin (found in Bayer) could increase the risk of side effects such as gastrointestinal bleeding. However, acetaminophen (Tylenol) can typically be taken along with Aleve, as it does not have the same risk profile. Always consult with a healthcare provider for personalized advice, especially if you have underlying health conditions or are taking other medications.

For further information and specifics about pain relievers, you can check this link: What's the Difference?.

Sources

Pain Relievers --- What's the Difference? - Baton Rouge GeneralExcedrin Alternatives Compared - Drugs.comTylenol, Bayer, Advil, and Aleve: What's The Difference?Is Acetaminophen, Ibuprofen, or Aspirin Best for Headaches?The 5 Most Effective Headache Medicines Across Expert ReviewsKnow the Difference Between Your Pain RelieversExcedrin Extra Strength vs. Tylenol Extra Strength

Related Questions

Is Tylenol or Excedrin better for headaches?

Is Tylenol or Bayer better for headaches?

Which pain reliever is best for headaches?

Are Tylenol and Bayer the same?