Researchers have found that there is a strong correlation between certain genetic variations in the SORT1 gene and levels of cholesterol in the body. However, these variations do not seem to have any association with cardiovascular disease. Additionally, the study also found that the PSRC1 gene in the cholesterol gene cluster is significantly associated with coronary artery disease due to two SNPs that control plasma levels. Similarly, the SORT1 gene, which encodes for the protein sortilin, has been linked to cardiovascular disease. Despite being the first gene to be evaluated for its role in LDL levels and risk of CHD, further research is needed to fully understand its mechanism. These findings highlight the potential contribution of genetic markers in identifying cardiovascular risk factors.