Studies have highlighted the substantial impact of the LPA gene on cardiovascular disease due to its influence on lipoprotein (a) [Lp(a)] levels. Elevations in Lp(a) concentrations are closely linked to an amplified risk of coronary heart disease (CHD), with the LPA gene being a key regulator. Notably, two distinct SNPs within the LPA gene have been identified as strongly associated with Lp(a) levels and the susceptibility to CHD. A comprehensive meta-analysis has further reaffirmed the correlation between these specific SNPs and CHD. Nevertheless, the precise relationship between Lp(a) levels and the risk of CHD necessitates further exploration, particularly in terms of predicting future risks to enhance our understanding of the interplay between Lp(a) and CHD.

Sources

Elevated lipoprotein(a) and genetic polymorphisms in the LPA gene may predict cardiovascular events - PMC - NCBILPA Gene, Ethnicity, and Cardiovascular Events | Circulation - AHA JournalsLipoprotein(a): Genotype–Phenotype Relationship and Impact on Atherogenic Risk - NCBIAssociation between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcificationGenetic Variants in the Apolipoprotein(a) Gene and Coronary Heart Disease - AHA JournalsThe impact of SNP rs3798220 on the LPA gene in atherosclerotic disease - Atherosclerosis

Related Questions

Are SNPs related to cardiovascular disease?

What is LPA in cardiology?

What is the SNP for the LPA gene?

What gene causes high LPA?