According to recent studies, variations in and around the Cholesteryl Ester Transfer Protein (CETP) gene have been linked to the levels of HDL and the risk for coronary heart disease. These genetic variants may also play a role in cardiovascular resilience during aging. The CETP gene is responsible for producing a protein essential in the reverse transport of cholesteryl ester. By analyzing these genetic variations, the potential risks and benefits of lifelong lower levels of CETP can be assessed. Some mutations in the CETP gene have been associated with coronary artery disease. Multiple studies have shown that these genetic polymorphisms increase the risk of cardiovascular diseases and contribute to abnormal lipid profiles. Overall, this highly polymorphic region in the CETP gene may have a significant impact on cardiovascular risk, as shown by various risk scoring methods. Research efforts have also focused on the potential protective effects of inhibiting the CETP protein.