Pernicious Anemia

Pernicious anemia is an autoimmune condition that causes vitamin B12 deficiency. It is more prevalent in those with northern European or African ancestry and results in megaloblastic anemia. The disease involves inflammation in the stomach and difficulty absorbing vitamin B12 in the small intestine. An inadequate amount of intrinsic factor, due to auto-antibodies, is a key aspect of the disorder.

Pernicious anemia is an autoimmune condition that leads to a deficiency of vitamin B12. This condition is more common among individuals with northern European or African ancestry and is associated with the development of megaloblastic anemia. The underlying mechanism involves inflammation in the stomach and impaired absorption of vitamin B12 in the small intestine. Notably, a key aspect of the disorder is the insufficient production of intrinsic factor due to the presence of auto-antibodies.

Sources

Pernicious Anemia: Definition, Symptoms, Causes & Treatment - Cleveland ClinicPernicious Anemia - Symptoms and Causes - Penn MedicineVitamin B12–Deficiency Anemia | NHLBI, NIHPernicious Anemia - StatPearls - NCBI BookshelfPernicious Anemia: Symptoms, Causes, Treatment, and More - HealthlinePernicious Anemia: Practice Essentials, Pathophysiology, Etiology - Medscape Reference
Pernicious Anemia: Symptoms, Causes, Diagnosis, and TreatmentPernicious Anemia: What It Is, Causes, Signs, Symptoms, and More ...

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