Chemical compatibility testing for propofol involves evaluating its compatibility with other drugs or substances. One study utilized methods such as High-Performance Liquid Chromatography (HPLC) and mass spectrometry to assess the compatibility of propofol with 23 other drugs. The findings indicated incompatibility with 23 out of the 36 drugs tested.

In addition to HPLC and mass spectrometry, the study also explored two new methods for determining compatibility with propofol: adding methylene blue or separating the aqueous phase. These methods offer alternative approaches to evaluating the chemical compatibility of propofol with other substances.

Furthermore, physical parameters such as an increase in emulsion droplet size can be indicative of incompatibility with propofol. These methods collectively provide a comprehensive approach to assessing the chemical compatibility of propofol with other drugs and substances.

Sources

Physicochemical compatibility and emulsion stability of propofol with commonly used analgesics and sedatives in an intensive care unit - PMC - NCBISystematic review of the stability and compatibility of propofol injection - PMC - NCBISystematic review of the stability and compatibility of propofol injection - TermediaCompatibility of propofol, fentanyl, and vecuronium mixtures designed for potential use in anesthesia and patient transport - ScienceDirectPropofol Compatibility with other Intravenous Drug Products—Two New Methods of Evaluating IV Emulsion Compatibility - Sage JournalsIncompatibility of Propofol Emulsion with Anesthetic Drugs - ASA Publications

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