Hypothesis That Explains The Development Of Alzheimer's Disease.
The amyloid hypothesis is the most widely recognized theory about Alzheimer's disease, and it explains the formation of senile plaque. Other theories include Tau, cholinergic neuron damage, oxidative stress, and inflammation. The calcium homeostasis hypothesis suggests that Aβ can disrupt calcium levels. The original amyloid hypothesis was based on the discovery of the APP gene on chromosome 21. Another theory, the presenilin hypothesis, suggests that dysfunction of PS1 contributes to neurodegeneration and dementia in AD.
One of the primary hypotheses explaining the development of Alzheimer's disease is the amyloid hypothesis. This hypothesis is the most widely recognized theory about Alzheimer's disease and is focused on the formation of senile plaques. Other theories include the Tau hypothesis, which focuses on the role of tau protein in the disease, cholinergic neuron damage hypothesis, oxidative stress hypothesis, inflammation hypothesis, and calcium homeostasis hypothesis, which suggests that Aβ can disrupt calcium levels. Additionally, the presenilin hypothesis suggests that dysfunction of presenilin 1 (PS1) contributes to neurodegeneration and dementia in Alzheimer's disease. These hypotheses collectively provide various perspectives on the complex underlying mechanisms of the disease.
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