The current evidence regarding creatine and its effects on liver health indicates a nuanced situation. Here are the key points derived from various sources:

1. General Safety: For healthy individuals, studies suggest that creatine, when used correctly, does not generally cause liver damage. A source from QNT emphasizes that there is no significant evidence to suggest liver damage from creatine supplementation in healthy people. Link to QNT.

2. Specific Concerns: However, individuals with pre-existing liver conditions, such as liver disease, are advised against taking creatine. The Mount Sinai health library suggests that people with liver disease should avoid creatine supplementation due to potential risks. Link to Mount Sinai.

3. Animal Studies: Some research involving animal models indicates that long-term high doses of creatine could potentially adversely affect liver structure and function in sedentary rats, though the implications for humans may differ significantly. Link to PMC.

4. Impact on Liver with Alcohol: Another study found that creatine supplementation could exacerbate liver injury when combined with ethanol, indicating that it might increase oxidative stress and inflammation in certain circumstances. This suggests caution for individuals who consume alcohol regularly. Link to ScienceDirect.

5. Fibrosis and Other Conditions: There is no increased risk of serious liver conditions, like fibrosis or cirrhosis, associated with creatine use compared to non-users, according to further studies. Link to PMC.

In summary, while creatine is generally safe for healthy users, those with underlying liver conditions or who consume alcohol should exercise caution. Always consult with a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health concerns.

Sources

Creatine consumption and liver disease manifestations in ...Effects of High-Dose Creatine Supplementation on Kidney and Liver ...Creatine supplementation protects against diet-induced non ...Creatine Information | Mount Sinai - New YorkCreatine - Mayo ClinicCreatine supplementation exacerbates ethanol-induced hepatic ...Creatine: Kidney and Liver Dangers and Risks? - QNT

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