The X-Score is a consensus scoring function that uses three different methods to accurately represent the contribution of desolvation in protein-ligand binding. In this perspective, different types of scoring functions are reviewed, including force-field, empirical, and knowledge-based functions. With the need for more precise scoring techniques, new scoring functions based on physics-based descriptors are necessary. Traditional consensus methods use an average score or rank from different docking programs. The four general classes of scoring functions include empirical, force-field-based, knowledge-based, and comparison approaches. Knowledge-based scoring functions use pair-wise energy potentials from known ligand-protein interactions. MoDock is an effective approach that combines multiple scoring functions to improve prediction accuracy.