Here are 20 key facts about Ceftriaxone, commonly known as Rocephin:

1. Classification: Ceftriaxone is a third-generation cephalosporin antibiotic, which belongs to the beta-lactam family of antibiotics. Source: IDStewardship.

2. Mechanism of Action: It works by inhibiting bacterial cell wall synthesis, effectively killing susceptible bacteria or preventing their growth. Source: Mayo Clinic.

3. Broad Spectrum: Ceftriaxone is effective against a wide range of bacteria, including both Gram-positive and Gram-negative organisms. Source: DrugBank.

4. Common Uses: It is used to treat various infections, including pneumonia, skin infections, urinary tract infections (UTIs), and certain types of meningitis. Source: WebMD.

5. Sexually Transmitted Infections: Ceftriaxone is also indicated for the treatment of gonorrhea and pelvic inflammatory disease, both of which are sexually transmitted infections. Source: MedlinePlus.

6. Administration: Ceftriaxone is generally administered via injection, either intramuscularly or intravenously, making it suitable for outpatient and inpatient settings. Source: RxList.

7. Dosage Adjustments: Dosage may need to be adjusted in patients with renal impairment, as Ceftriaxone is primarily eliminated by the kidneys. Source: Reference Medscape.

8. Not Effective for Viral Infections: It's important to note that Ceftriaxone will not treat viral infections, such as colds and flu. Source: Mayo Clinic.

9. Potential Side Effects: Common side effects include pain at the injection site, rash, diarrhea, and allergic reactions. Source: WebMD.

10. Serious Reactions: Although rare, severe allergic reactions (anaphylaxis) and Clostridioides difficile-associated diarrhea can occur with Ceftriaxone use. Source: RxList.

11. Drug Interactions: Ceftriaxone may interact with other medications, including anticoagulants, which can enhance bleeding risk. Source: DrugBank.

12. Use in Children: Ceftriaxone is often used in pediatric settings and is considered safe for use in children and infants for specific bacterial infections. Source: Reference Medscape.

13. Plasma Concentration: The drug reaches maximum plasma concentrations within 1-2 hours after administration. Source: IDStewardship.

14. Usage in Surgery: It may be used prophylactically in certain surgeries to prevent infections. Source: RxList.

15. Stability: Ceftriaxone is stable in a variety of conditions but should be stored at room temperature and protected from light. Source: IDStewardship.

16. Hepatic Excretion: While primarily excreted by the kidneys, some Ceftriaxone is also secreted via the liver and bile. Source: DrugBank.

17. Pregnancy Category: Ceftriaxone is classified as a category B drug for use during pregnancy, indicating that it is generally considered safe but should be used only if clearly needed. Source: WebMD.

18. Cross-Reactivity: Patients with a penicillin allergy may experience cross-reactivity to Ceftriaxone and should be monitored closely. Source: RxList.

19. Bacterial Resistance: The emergence of bacterial resistance to Ceftriaxone is an ongoing concern, and susceptibility testing is recommended before use. Source: DrugBank.

20. Emergency Use: In cases of severe bacterial infections, Ceftriaxone can be used in combination with other antibiotics to enhance efficacy and cover a broader range of pathogens. Source: MedlinePlus.

These facts illustrate the vital role of Ceftriaxone in treating bacterial infections, along with its mechanisms, applications, and precautions.

Sources

Rocephin (Ceftriaxone): Side Effects, Uses, Dosage ... - RxListCeftriaxone (Rocephin): Uses, Side Effects, Interactions ... - WebMDCeftriaxone: Uses, Interactions, Mechanism of Action - DrugBankCeftriaxone Injection: MedlinePlus Drug InformationCeftriaxone dosing, indications, interactions, adverse effects, and moreCeftriaxone (injection route) - Mayo ClinicCeftriaxone (Rocephin) - IDStewardship

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